I suppose that mixing it with alcohol could increase the risk of death just like with opiates. I have known a lot of people that take a huge amount daily with very few effects.
I have taken it for pain for a few years. Hard to tell how much I take because I fill my own capsules. I take usually 10-15 capsules a night. Probably close to 10-15 grams. I have doubled that on nights with a lot of pain. I am also a big guy that it is used to it.